Defining questions

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To optimize outcomes, we define questions to address key evidence components and optimize value. For instance:

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• Population/setting: Use representative settings and populations,

• Interventions/comparators: Make randomized comparisons of interventions to each other and usual care,

• Outcomes: Use outcomes that directly capture key process, behavioral, and clinical outcomes of systems, providers, and patients,

• Timeframes: Use timeframes that align with the likely interval for key effects, and

• Other: Examine key mediators and moderators that are likely to drive improvements in work.

 

A common structure for our questions is below.